Simultaneous Analysis of Antiarrhythmic Drugs in Human Blood Plasma Using the Fully Automated Sample Preparation LC/MS/MS System

Introduction

During drug treatment with drugs that pose administration management difficulties, such as drugs with a narrow therapeutic range or drugs with a fine line between toxicity and effectiveness, the blood concentration of drugs in patients is measured to determine the optimal dose and method of administration for individuals based on pharmacokinetic and pharmacodynamic analysis. Application News No. C123 introduced an investigation into optimizing the analysis workflow including pretreatment by using the fully automated sample preparation LC/MS/MS system that comprises the CLAM-2000 fully automated LCMS sample preparation unit and a high performance liquid chromatograph mass spectrometer. This article introduces a study which achieves a fast and simultaneous analysis workflow of six antiarrhythmic drugs with the fully automated sample preparation LC/MS/MS system.

August 9, 2017 GMT