Residual Solvents Analysis in Pharmaceutical Products (Part 7) - Thermostatting Dependencies of Aqueous Solution /Water Dilution Effect on DMSO Solution

Introduction

In Shimadzu Application News No. G209 and G223, comparison was made for GC sensitivity depending on dilution solvent. Since many of the residual solvents in pharmaceutical products do not easily dissolve in water, these solvents in aqueous solutions can be analyzed with relatively good sensitivity using headspace GC. Introduced here is the change in detection sensitivity due to changing of the thermostatted temperature of an aqueous solution. Also introduced here is an investigation of how detection sensitivity changes by the dilution of a DMSO solution using water.

September 5, 2005 GMT