Impurity Analysis of Drugs Using Shim-pack XR-Phenyl Column

Introduction

Selection of the appropriate column and setting the separation conditions are extremely important in impurity analysis. Although an ODS column is used most of the time, use of phenyl columns is increasing recently with the aim of improving separation. In particular, it is believed that the effectiveness of many pharmaceutical substances is linked to utilization of the aromatic ring π-π interaction. Here we introduce examples of impurity analysis of nitrendipine and nifedipine using the Prominence UFLC and LCMS- 2020.

December 16, 2010 GMT