Effectiveness of Fast Scanning Measurement Using GCxGC-MS

Introduction

A GC×GC-MS system (Fig. 1) incorporates 2 chromatographic columns with different separation characteristics, non-polar and polar columns, permitting acquisition of comprehensive 2-dimensional chromatograms by orthogonal separation according to boiling point and polarity. Excellent separation is obtained with an extremely narrow chromatographic peak width on the order of hundreds of milliseconds. Even compounds that are difficult to separate by conventional GC-MS can now be separated using GC×GC-MS. It is an extremely effective system for qualitative analysis, which requires the separation of target substances in complex matrices, common in natural substances, as well as impurity analysis. However, due to the requirement for MS capable of very fast scan speed, quadrupole MS systems have been considered to be unsuitable for GC×GC-MS. The GCMS-QP2010 Ultra resolves this problem with a scan speed as high as 20,000 u/sec.

August 9, 2011 GMT