Determination of Drugs in Blood Plasma by "Co-Sense for BA" (Part 6)

Introduction

Co-Sense for BA, an automated pretreatment column- switching HPLC system for analyzing biological samples such as blood plasma and serum, is used as an effective tool in satisfying the requirements for high- throughput analysis in pharmacokinetics testing and metabolic research. On the other hand, to further increase analysis throughput in recent years, high-throughput columns with 3μm and smaller diameter spherical particles and monolithic columns which consist of a single rod of silica-based material are becoming popular. In particular, since the inlet pressure in monolithic columns is low, analysis can be performed with high flow rate, making them applicable for high throughput analysis. Introduced here is an analysis of drugs in plasma in an investigation of shortened analysis time using a monolithic type column as the analytical column. For more information on the Co-Sense for BA principle and related application examples, refer to Application News No. L285, 286, 293, 305 and 307.

October 19, 2004 GMT