Analysis of Cold Medicine Using Newly Developed "Shim-pack MAqC-ODS I" Column

Introduction

In Application News No. L459, we introduced the simultaneous analysis of water-soluble vitamins using the Shim-pack MAqC-ODSIcolumn. Use of the Shim-pack MAqC-ODSIcolumn makes it possible to achieve retention of highly polar basic compounds without the use of ion-pair reagents in the mobile phase, thereby permitting the application of gradient elution. As a result, improved sensitivity and time savings can be achieved in the simultaneous analysis of highly polar basic compounds and other substances. Similarly to water-soluble vitamins, pharmaceutical substances also contain many basic compounds having high solubility in water. Here, using the Shim-pack MAqC-ODS I column, we introduce an example of analysis focusing on substances that are typically included as active ingredients in over-the-counter cold medicines.

August 1, 2014 GMT