Study of a Method for Coping with Matrix Effects in Pesticide Residue Analysis Using GC/MS/MS

Introduction

One of the issues cited in the analysis of pesticide residues in food using GC/MS/MS is the matrix effect that causes abnormal recovery rates. The matrix effect is a phenomenon where the matrix sample has a higher response for pesticide residues than the standard sample. It occurs because adsorption and decomposition occur at the active site with standard samples where there is no matrix, but in cases where there is a matrix the matrix coats the active site. The method of adding an analyte protectant (AP) is used as a countermeasure to reduce the matrix effect. Polyethylene glycol (PEG) 300 can be cited as a representative AP. K. Mastovska et al. have also reported a method where a sample of mixed ethylglycerol, sorbitol, and gulonolactone are used as a useful AP mixture. In this article, we report on the results of studying a method for coping with matrix effects when PEG300, and a combination of AP, were used.

June 25, 2023 GMT