Analysis of Favipiravir in Human Plasma Using Fully Automated Sample Preparation LC/MS/MS System

Introduction

Favipiravir (brand name: Avigan), which was developed by FUJIFILM Toyama Chemical Co., Ltd, is one of the RNA polymerase inhibitors used for treating influenza. In Application News C229, we introduced a robust, highly- sensitive analysis using LC/MS/MS with manual pretreatment. However, manual pretreatment of plasma samples entails a certain level of workload. This report introduces a method of analyzing favipiravir using a fully automated sample preparation LC/MS/MS system that can reduce variation between procedures, sample mix-ups, and risk of exposure to the samples.

October 22, 2020 GMT