Isolation and identification of Fluticasone degradation impurities by UFPLC

Introduction

Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma. Fluticasone Proprionate is marketed under several different brand names such as Flonase. Fluticasone propionate is also available as a combination product of Azelastine Hydrochloride and Fluticasone Propionate called Dymista^TM . Dymista^TM is indicated in patients over 12 years old for symptomatic relief of seasonal allergic rhinitis. Prominence UFPLC, Ultra Fast Preparative and Purification Liquid Chromatograph (Shown in Figure 2.), which enables fast recovery of highly purified target compounds from complex samples such as organic synthesis reaction mixtures and natural products. Prep LC is a widely used technique in many research development and manufacturing applications, including the synthesis of new drug compounds, the discovery of active components in natural products, and as a mechanism to collect large amounts of unknown compounds in foods and drugs for subsequent structural analysis.

January 7, 2020 GMT