Isolation and identification of Atorvastatin degradation impurities by UFPLC

Introduction

Atorvastatin is an antilipemic drug belonging to the statins class, whose reference drug is Pfizer’s Lipitor. It is used to reduce the levels of lipoproteins rich in cholesterol and reduce the risk of coronary artery disease. The drug in question is commonly sought after by pharmaceutical industries that produce generic drugs, due to the fact that the drug has a high value price, it is consumed globally, and its patent expired in late 2010. Atorvastatin has been found to degrade under acid and basic conditions. Prominence UFPLC, Ultra Fast Preparative and Purification Liquid Chromatograph, which enables fast recovery of highly purified target compounds from complex samples such as organic synthesis reaction mixtures and natural products. Prep LC is a widely used technique in many research development and manufacturing applications, including the synthesis of new drug compounds, the discovery of active components in natural products, and as a mechanism to collect large amounts of unknown compounds in foods and drugs for subsequent structural analysis.

January 7, 2020 GMT