Qualitative/Quantitative Analysis of Drugs in Whole Blood by DPiMSQT and Nexera™ installed LCMS-9030

User Benefits

- Qualitative screening using the DPiMS QT kit can be conducted with a sample preparation time of about 5 min and measurement time of approximately 0.5 min. - Simple switching to the Nexera ultra-high performance liquid chromatograph is possible. - Once data are acquired, it is possible to extend the target compounds later without storing samples.

Introduction

In analysis of drugs and poisons in forensic medicine and scientific criminal investigations, it is necessary to identity drugs and report the quantitative results quickly. For this, development of an efficient workflow that enables exhaustive qualitative/quantitative analysis of all relevant components is required. This Application News introduces a workflow consisting of qualitative analysis using a combination of an LCMS-9030 quadrupole time-of-flight mass spectrometer and DPiMS QT which is a probe kit of electrospray ionization unit followed by quantitative analysis by a combination of an LCMS-9030 and a Nexera X3 ultra-high performance liquid chromatograph. Use of the DPiMS QT and Nexera with one LCMS-9030 enables quick completion of the entire process from high-speed qualitative screening of drugs to quantitation. By reducing the number of samples necessary in the quantitative analysis, this technique also makes it possible to achieve high efficiency in the measurement and reduce the consumable items used in the quantitative analysis.

September 24, 2021 GMT