Go Faster with Low-Pressure GC-MS Analysis

User Benefits

- GCMS-QP2020 NX supports high throughput analysis using fast and low-pressure GC-MS - Chromatographic peak definition improves with higher quadrupole scanning speed - Save up to 80% of analysis time in routine screening analysis with fast and low-pressure GC-MS

Introduction

Gas chromatography mass spectrometry (GC-MS) is a well- developed and robust method used for the analysis of volatile and semi-volatile compounds in various application fields. The increasing demands for higher sensitivity and sample throughput have spurred decades of development and innovation. Innovations in GC column and GC hardware are constantly being sought out to improve the efficiency of GC-MS analysis. Considerable efforts in these areas have enabled a substantial reduction of GC-MS analysis time with minimal compromise on the chromatographic resolution. These techniques are known as fast GC-MS and low-pressure GC-MS (LPGC-MS) methods. The fast GC-MS method is based on the usage of narrow-bore columns and has successfully transitioned from research to commercial use. Nowadays, it is increasingly being adopted for routine analysis. As for the LPGC-MS method, it is undergoing the transition phase and its development has only been recently spurred by the commercial availability of a low- pressure GC column kit. The kit eliminates the technical difficulty encountered in the adoption of the LPGC-MS method and is expected to broaden its utilization. These high sampling throughput methods are expected to drastically reduce the GC-MS analysis while maintaining similar accuracy in analysis. In this article, we will demonstrate the robustness of the Shimadzu single quadrupole system, GCMS-QP2020 NX, to support the utilization of fast GC-MS and LPGC-MS methods, with a focus on the latter. When coupled with the high scanning speed capability of the Shimadzu GCMS-QP2020 NX, the LPGC-MS method could be utilized for rapid screening in various application fields.

April 27, 2022 GMT