Visualization of Lanthanum Precipitates in Gastric Tissue by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging

Introduction

Various applications of mass spectrometry imaging (MS imaging) using laser ablation-inductively coupled plasma-mass spectroscopy (LA-ICP-MS) as a method for imaging metals in living organisms have been reported in recent years. Among those applications, LA-ICP-MS is frequently used in pharmacokinetic analysis and toxicity evaluation of drugs that contain metals. This Application Note reports the results of visualization of the distribution of lanthanum in gastric tissue by LA-ICP-MS, using biopsy specimens from a patient who developed gastritis after administration of lanthanum carbonate.

June 28, 2022 GMT