Fast Analysis of Ciclesonide Inhalant by Online SFE-SFC-QTOFMS

User Benefits

- Online SFE-SFC-QTOFMS can be used to quickly screen for impurities in pharmaceuticals. - A wide variety of impurities can be analyzed simultaneously with almost no sample pretreatment.

Introduction

Checking the content of active ingredients and impurities is essential for maintaining pharmaceutical quality, so establishing a quick and convenient screening method would help shorten development periods and promote practical use of pharmaceuticals. Online SFE-SFC-QTOFMS systems use a combination of supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) for extracting components with supercritical fluid in an extraction vessel, injecting the extracted components into an SFC unit for online column separation, followed by accurate mass analysis of separated components in a quadrupole-time of flight (QTOF) mass spectrometer system. The online SFE-SFC system can also add a polar organic solvent to supercritical carbon dioxide fluid as a modifier to enable extraction and separation of components with a wide range of polarities. This article describes an example of using the online SFE-SFC- QTOFMS method for screening analysis of active ingredients and impurities in the drug Alvesco, a ciclesonide inhalant used to treat bronchial asthma.

July 28, 2022 GMT