Contaminant Analysis of Pharmaceuticals (Tablets) Using AIRsight Infrared/Raman Microscope

User Benefits

- Use of AIRsight makes it possible to acquire both infrared and Raman spectra at the same location without moving the measurement target sample. - Highly accurate qualitative analysis is possible by measuring the infrared and Raman spectra at the same location. - Even microscopic contaminants on pharmaceuticals (tablets) can be analyzed by simple operation.

Introduction

In recent years, consumers have shown heightened concern about contamination of products by foreign matter, and demand for analysis to respond to this problem has also increased. Although news reports that contaminants have been discovered in some foods and pharmaceuticals have appeared from time to time, it is difficult to eradicate this problem completely, as the causes of contamination are assumed to include various processes such as contamination of raw materials at the time of purchase, contamination of the product due to deterioration of component parts of the production line, and contamination of the product by the consumer. The types of foreign matter are also diverse, including not only organic materials such as human hair, plastics, and rubber, but also oxides, metal fragments, and other inorganic substances. For these reasons, higher accuracy is required in qualitative analysis in order to identify the cause of contamination. The AIRsight Infrared/Raman microscope is a new microscope in which a Raman unit is incorporated in an infrared microscope, making it possible to carry out both Raman and infrared analysis with a single instrument, even though separate instruments had been required until now. Since the infrared spectrum and Raman spectrum can be acquired at the same location, without moving the sample, the accuracy of qualitative analyses of micro regions is dramatically improved. Operation is also simple because both the infrared and Raman measurements can be controlled with one software program, AMsolution. This article introduces an example of measurement of a contaminant adhering to the surface of a pharmaceutical (tablet) (hereinafter, “tablet”) by micro-infrared spectroscopy and micro-Raman spectroscopy.

November 16, 2022 GMT