Example of Observing Tablet Using a Microfocus X-Ray CT System

User Benefits

- The distribution of granules inside the tablet can be easily visualized non-destructively by CT imaging. - The thickness of the multi-layered membrane can be analyzed without cutting and polishing the tablet, which helps in quality control of the product.

Introduction

Medicines are produced in a variety of forms, including powders, tablets, and capsules, depending on their intended use and purpose. Among them, tablets are widely used because they are easy to carry, store and take. The distribution of granules and voids in a tablet affects the rate at which the active ingredient in the tablet dissolves into the bodily fluids, and is a factor that affects the efficacy and safety of the medicine. In addition, with tablets whose surfaces are coated with a membrane, the thickness of the membrane changes the organ in which the internal components are eluted, so it is important to control the thickness of the membrane in order to achieve a strong effect while reducing side effects of the medicine. A useful tool for non-destructively observing the distribution of granules, voids and the thickness of the membrane is the Microfocus X-ray CT system. This article introduces an example of a tablet observed using the microfocus X-ray CT system, inspeXio SMX -225 CT FPD HR Plus.

December 25, 2022 GMT