Methods for the determination of residual veterinary drugs in Raw Milk using LCMS-8050

User Benefits

- Modified QuEChERS and SPE combined with Ultra-fast technologies of LCMS-8050 for quantification of veterinary drugs residues at trace levels. - Method covering different drugs with different chemical properties - Shorter analytical time can provide more high throughput analyses.

Introduction

The use of veterinary drugs in dairy farming is important for the prevention and treatment of diseases in dairy cows. However, veterinary drugs may remain in raw milk due to the misuse or withdrawing period of drugs, which can lead to health issues for consumers as milk is an important food in the diet, especially for infants and children. Hence to ensure the safety of milk products, the safety regulation for veterinary drug residues in food has been strengthened. To meet these stringent regulations a quantitative and highly sensitive analytical method is required. The aim of this study is to develop a sensitive analytical method covering this wide range of different veterinary drugs. Based on these requirements, Shimadzu has developed and validated 4 simple, sensitive and high throughput, multiresidue methods for the determination of available veterinary drugs (total 69) in milk using LCMS-8050. The extraction was performed with modified QuEChERS[1] method and SPE. Method I covers 44 compounds, Method II covers 15 compounds, Method III covers 4 compounds and Method IV covers 6 compounds.

March 1, 2023 GMT