Strength Evaluation of Pharmaceuticals and PTP Packaging

User Benefits

- Enables strength evaluations required for the development and quality control of pharmaceuticals and PTP packaging. - Meets test data integrity and audit trail requirements by using LabSolutions^TM AG.

Introduction

In the development and quality control of pharmaceuticals and pharmaceutical packaging, it is necessary to ensure their efficacy and safety. Therefore, various evaluations are performed. For example, tablets must be hard enough to not crack or split during their manufacture and transport. But if they are too hard, their solubility when swallowed could be reduced, so they must be manufactured to the appropriate hardness. The packaging of pharmaceuticals must also protect them from moisture and light so that their quality does not deteriorate. Typically, pharmaceuticals are enclosed in plastic or aluminum using PTP sheets, and the packaging is designed to dispense them by pressing the sheet. Therefore, the packaging must be manufactured so that the force to push them out is appropriate. Testing machines are used to perform these evaluations. Here the three types of tests used in the strength evaluations are introduced: compressive tests on pharmaceuticals, 3-point bend tests on pharmaceuticals, and push-out tests on PTP sheets to evaluate the strength of PTP packaging.

March 28, 2023 GMT