Fully Automated Simultaneous Analysis of Cephem Antibiotics in Serum by LC-MS/MS

User Benefits

- Simultaneous analysis of 12 different cephem antibiotics is possible. - The entire process is automated, from biological sample preparation to LC-MS/MS measurement. - Good reproducibility is achieved with a measurement cycle time of 7 minutes.

Introduction

Cephem antibiotics like penicillin and carbapenems are a type of β-lactam antibiotic used in oral medicines and injectable solutions. Cephem antibiotics are said to be effective for various illnesses because they have a high safety profile with a low frequency and degree of side effects. Here, we introduce a simultaneous analysis method for cephem antibiotics in blood plasma by LC-MS/MS using the CLAM-2030, which enables fully-automated pretreatment of biological samples. The CLAM-2030 can be used to reduce specimen mixups and variations in procedure. There are 50 main cephem antibiotics, of which 12 components (cephadroxil, cefapirin, cefaclor, cephalexin, cefuroxime, cefotaxime, cefoxitin, cefazolin, cepharazine, cefoperazone, cefamandole, and cephalothin) were targeted in this analysis system.

March 28, 2023 GMT