Ultra-Sensitive Dynamic Headspace GC-MS/MS Method for Trace Level Quantitation of Nitrosamines in Deferiprone API

User Benefits

- Dynamic headspace achieves high sensitivity for trace level estimation at desired quantitation levels. - Compared to static headspace, dynamic headspace with multi-injection count option provides flexibility during method development.

Introduction

Overview : Regulatory bodies related to pharmaceutical industry have extensively investigated the presence of genotoxic impurities, called Nitrosamines (NSA), in many drugs. Deferiprone is an iron chelator used to treat patients with transfusional iron overload caused by thalassemia syndromes. Hence it is imperative to make Deferiprone drug available with safe levels of NSA.

June 13, 2023 GMT