Analysis of Per- and Polyfluoroalkyl Substances (PFAS) Using Triple Quadrupole Mass Spectrometer Part 2 -Milk-

User Benefits

- The optimized procedure for pretreatment and LC-MS/MS analytical conditions enable accurate quantification of thirty major PFASs targeted by AOAC SMPR from 0.01 μg/kg in milk. - The method allows the initiation of PFASs analysis in food.

Introduction

Per- and Polyfluoroalkyl Substances (PFASs) are a collective name for more than four thousand organofluorine compounds. Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are representative compounds of PFAS. They are used in a wide range of applications, such as fire retardants, food packaging materials, and non-stick coatings, due to their water-repellent, oil-repellent, heat-resistant, and chemical-resistant properties. Due to their structural stability, PFAS widely remains in the environment. Recent studies have revealed that PFAS can transfer into dairy products when dairy cows ingest feed or water contaminated with PFAS. There are concerns about the potential health risks caused by human ingestion of PFAS-contaminated dairy products. Therefore, quantitative assessment of PFAS levels in dairy products should be important. To monitor PFAS concentrations in dairy products, a highly accurate and sensitive quantification method is essential. This application news introduces a quantitative analysis of PFAS in dairy milk with LC-MS/MS. Thirty PFASs targeted by AOAC INTERNATIONAL were analyzed and evaluated by spike recovery test. By optimizing the analytical conditions, good recoveries were obtained for all compounds.

April 16, 2025 GMT