Rapid Analysis of Anticoagulants in Plasma Using LC-MS/MS

User Benefits

- Nexera X4 significantly improves solvent delivery responsiveness, providing short analysis cycle time and rapid processing of a large number of samples. - High-speed needle internal/external rinsing function completes needle cleaning within analysis time. - Eight anticoagulants in plasma can be quantified with simple pretreatment of just deproteinization.

Introduction

In pharmacokinetic studies, blood drug level measurement is performed to clarify the dynamics of drug absorption, distribution, metabolism, and excretion within human body. High-speed analysis is paid important attention because of rapid requirement of analytical results and huge number of samples to treat. This article presents ultra-high-speed analysis for eight anticoagulants involving five direct oral anticoagulants/new oral anticoagulants (DOACs/NOACs) performed by combination use of Nexera X4 high-performance liquid chromatograph and triple quadrupole mass spectrometer. Nexera X4 achieves significantly improved solvent delivery responsiveness through four independently actuated plungers and pressure feedback mechanism. This provides reliable results in ultra-high-speed analyses as is described in this article.

February 24, 2026 GMT