Achieving Solvent Reduction and Lower Running Costs with Nexera X4

User Benefits

- Using narrow-bore columns enables a substantial reduction in solvent consumption. - Nexera X4 features a low-dispersion design with minimized internal volume, enabling sharp peak shapes even when using narrow-bore columns.

Introduction

In recent years, there has been growing interest in sustainability within analytical laboratories. In liquid chromatography, the large volumes of organic solvents used as mobile phases present challenges from both environmental and cost perspectives. One approach to reducing solvent consumption is to downscale analyses by using small-diameter columns. Such solvent-saving strategies not only contribute substantially to lowering running costs, but also reduce the amount of waste solvent, enabling more environmentally conscious laboratory operations. However, analytical downscaling requires effective suppression of band broadening within flow channels and highly accurate low-volume injections. Nexera X4 delivers exceptional instrument performance that meets these demands and provides stable analytical results even when small-diameter columns are used. This article presents a case study in which analysis was downscaled and solvent consumption was significantly reduced by combining Nexera X4 with a 1-mm-ID column (Shim-pack NovaCore C18-HB).

March 2, 2026 GMT