Simultaneous Analysis of 27 Antidiabetic Drugs in Whole Blood by LC–MS/MS

User Benefits

- 27 antidiabetic drugs with diverse chemical structures can be quantified in a single run. - Antidiabetic drugs can be detected with high sensitivity at concentrations of 0.1 ng/mL in whole blood - Analysis can be run on the same workflow and analytical conditions of “LC/MS/MS Forensic Toxicology Database.”

Introduction

Antidiabetic (glucose-lowering) drugs, mainly prescribed for the treatment of diabetes, include many classes with different mechanisms of action, such as biguanides, sulfonylureas (SUs), DPP-4 inhibitors, and SGLT2 inhibitors. Overdose or polypharmacy use of these drugs causes severe hypoglycemia. It can lead to the loss of consciousness and may result in falls, traffic accidents, and other serious incidents. In recent years, some antidiabetic drugs have been promoted on social media as “weight-loss drugs,” and their non-medical use for beauty care or diet purposes has become a social concern. In addition, these drugs have become easier to obtain through personal importation, raising concerns about adverse health effects from overdose or polypharmacy without medical supervision. This study introduces the evaluation results of a simultaneous LC-MS/MS method using the LCMS-8050RX for 27 antidiabetic drugs in blood.

May 19, 2026 GMT