High-Throughput Analysis of Drug Metabolites Using a Triple Quadrupole LC-MS/MS System

User Benefits

- The high-speed analysis time of 0.80 min contributes to higher throughput. - Nexera X4’s excellent high-speed gradient performance in combination with the LCMS-8060RX CoreSpray technology enables consistent and reliable trace quantitative analysis.

Introduction

In pharmacokinetic studies, drug concentrations in biological samples are analyzed to clarify the absorption, distribution, metabolism, and excretion of drugs in vivo. Because rapid results are required and a large number of samples must be handled, faster analytical methods are increasingly important. This report describes an example of high-throughput analysis of six drug metabolites using a system consisting of a Nexera X4 ultra high-performance liquid chromatograph and a LCMS-8060RX triple quadrupole mass spectrometer.

September 3, 2026 GMT