Trace Analysis Using the High-Sensitivity Cell of SPD-M40 X4 Photodiode Array Detector

User Benefits

- The high-sensitivity cell of the photodiode array detector SPD-M40 X4 enables highly sensitive detection of trace components. In addition, the detector provides good linearity (up to 3 AU), enabling quantitative analysis over a wide concentration range. - The low-dispersion injection mode of the autosampler minimizes peak dispersion caused by the system, contributing to enhanced sensitivity for the detection of trace components.

Introduction

Accurate quantification of trace components requires detection with a high signal-to-noise (S/N) ratio. Increasing the injection volume or sample concentration can be considered as approaches to improve S/N ratio. However, increasing the injection volume may adversely affect peak shape because the sample may not be properly retained at the column inlet due to the influence of the sample solvent. In addition, increasing the sample concentration may result in insufficient solubility of the sample. Therefore, when changes in injection volume or sample concentration are difficult, enhancing detector sensitivity is required for the detection of trace components. In this study, an example of highly sensitive detection of trace components using the photodiode array detector SPD-M40 X4 (high-sensitivity cell) installed in the Nexera X4 system is presented. In addition, the results of an evaluation of detector linearity are shown.

November 11, 2026 GMT