USP-Specified TOC System Suitability Test by TOC-LCPH

Introduction

The United States Pharmacopeia (USP) specifies the use of Total Organic Carbon (TOC) for management of organic impurities in purified water (PW) and water for injection (WFI). According to the USP, the TOC analyzer to be used for these analyses must satisfy the TOC system suitability testing requirement, and must be capable of detecting TOC at concentrations below 0.05 mg/L. Here, using the Shimadzu TOC-LCPH combustion catalytic oxidation type analyzer, we introduce examples of TOC system suitability testing and measurement of TOC at a concentration below 0.05 mg/L.

March 18, 2013 GMT