Real-Time Monitoring of Chemical Reactions

Introduction

In the field of chemistry, monitoring the reaction process and rate of chemical reactions is very important in order to accurately understand the type of reaction that is occurring. Probe electrospray ionization (PESI) is a direct ionization technique that uses a probe to ionize sampled target components by sampling a sample at a constant frequency with high voltage applied to the probe tip. This technique enables rapid monitoring of sample changes without the need for a chromatograph. The DPiMS-2020, which combines PESI with a mass spectrometer, enables accurate understanding of the progression of chemical reactions through real- time monitoring of changes in the molecular weight information of components targeted for analysis. This article introduces the result of using the DPiMS- 2020 to perform real-time analysis of the deprotection reaction of a peptide protecting group that was produced on a sample plate.

August 3, 2017 GMT