Method Optimization System Triple Capillary Column GC
Simultaneous Three-Column Analysis with a Single Sample Injection and No Column Replacement Provides More Efficient Investigation of Separation Conditions
Significantly Quicker Investigation of Separation Conditions
Due to the impurities or organic solvents that can remain in drugs, it is important to optimize the analytical method. However, investigating the analytical conditions for several columns with different liquid phases involves complex and time-consuming tasks, such as replacing the columns and waiting for the instrument to stabilize.
The Shimadzu Method Optimization System (Triple Capillary Column GC) simultaneously acquires separation information for three columns from a single sample injection. This significantly reduces analysis times, enabling more efficient investigation of separation using columns with different liquid phases by eliminating column replacement and by significantly reducing the time waiting for the instrument to stabilize.
Three-Column Simultaneous Analysis of 12 Organic Solvent Components
This is an example of the simultaneous three-column (Rtx-624, Rtx-WAX, and Rtx-1) analysis of 12 organic solvent components with the Method Optimization System (Triple Capillary Column GC).
It shows that a component inadequately separated in one column may be separated in a different column.
Such analysis results enable users to select the best column for a target component.
Easy Handling Easy Column Installation and Replacement
Columns are installed using the same graphite ferrules and nuts used for a normal single capillary column.
Tightening the graphite ferrules and nuts on the three columns eliminates concerns about gas leaks or a column coming loose during the analysis. (Compatible with 0.53 mm I.D. wide-bore columns.)
Optimal File Management for Investigating Separation Conditions The three chromatograms and the method file are stored in a single data file
The Shimadzu GCsolution and LabSolutions LC/GC workstations save the chromatograms obtained from the three columns and the analysis conditions used for data acquisition in a single data file. This provides a sound understanding of the analysis conditions used to acquire the data for each chromatogram, even if the analysis conditions were changed when investigating separation conditions.
Sample Configuration of a Method Optimization System (Triple Capillary Column GC)
This system incorporates three FIDs. (It does not include the analytical columns.)
|GC-2030 / Gas Chromatograph||1|
|FID-2030 Flame Ionization Detector (additional FID)||2|
|INJ three-way branch unit*1||1|
|Glass insert for split analysis*2||1|
|Inert glass wool*2||1|
The INJ three-way branch unit comprises one capillary three-way adaptor, one multiple-column hanger, and three INJ nuts. A capillary 2-way adaptor and an INJ 2-way branch unit are also available for dual capillary column systems, where two columns are connected.
One glass insert for split analysis and 2 g inert glass wool are supplied as standard with the GC-2030.
Precautions During Use
- It may not be possible to mount three columns inside the oven, depending on the column gauge size.
- If three different sized (bore, length, etc.) columns are selected, the carrier gas flow rate and sample branching ratio will differ for each column. Therefore, selecting three columns of the same size is recommended.
- Use a glass insert for split analysis.