Improved Analytical Workflow for Phospholipids by Nexera-e and Co-Sense for Impurities

Together, the comprehensive two-dimensional Nexera-e, offering exhaustive analysis of diverse compounds, and the Co-sense series, permitting high resolution and enrichment of specific fractions, make it possible to compare the overall compound patterns in the target sample. Combination of the Nexera-e and Co-Sense series also allows precise separation of the elution fraction of interest.
With this method, the two workflows consisting of the differential analysis of a sample with a complex matrix, and a detailed analysis of the compounds of those results to reveal differences, can be conducted simultaneously, quickly and conveniently. Here, we introduce an actual example using phospholipids.

Fig. 1 1D Reversed Phase Separation of Phospholipids

Fig. 2 2D Plot of All Positive MRM Transitions of Phospholipids