QuantaSep Adept 300
Single-use Chromatography Systems
Bench-Scale Automated Chromatography System
with Single-Use Flow Path for Clinical Production
The QuantaSep® Adept 300 is a single-use automated benchtop chromatography system capable of operating at flow rates of 10-100 mL/min or 30-300 mL/min, depending on the selected flow path. The integrated system features dual computer-controlled pumps, up to 12 buffer-selection valves, an inline mixer, filters, and six fraction-collection valves. Its capabilities include buffer switching, gradient formation, feed prefiltering, air ejection, conductivity and pH sensing both pre- and post-column, and flow control through a powerful and easy-to-use software. The software enables buffer and fraction switching based on process conditions and activates alarms in the event of overpressure or air leaks. All events are automatically logged and archived.
The QuantaSep Adept 300 hardware consists of control modules and a fluid-handling module integrated into a single, ergonomically designed counter-height cabinet. The benchtop unit can be cart-mounted for easy mobility. The computer that houses the control software can be integrated with or separated from the system, providing the option of remote operation. The system is compatible with 1 M NaOH and alcohol for CIP operations and can operate at 4 °C for cold-room processing.
Features
No Cleaning Validation Required
- Removable single-use flow path eliminates cross-contamination risk.
Dual Flow Range
- Accommodates two flow paths with flow rates of 10 to 100 mL/min or 30 to 300 mL/min.
Space Efficient
- Compact footprint allows installation on a benchtop inside a laminar flow hood or in a cold room.
Flexible and Stable Downstream Process
- Automates buffer delivery, column switching and fraction collection based on UV, pH and conductivity.
- "Active air trap" minimizes bubble-trap dilution.
Unattended 24/7 Production
- Fail-safe alarms and automated logging enable round-the-clock runs.
Automated GMP Reports
- Every event, alarm, and batch record logged and archived automatically.
Removable Flow Path
The flow path of this system is designed for easy removal. This eliminates the need for cleaning validation. Issues related to cross-contamination in switching columns or products are substantially minimized when the flow path can simply be replaced. Pinch valves and peristaltic pumps enable easy changing of the pre-fabricated tubing assembly along with the integrated sensor block, which can be easily removed and replaced as well.
Flow Diagram of the QuantaSep Adept 300
QuantaSep Software
The Right Combination of Simplicity and Power
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The intuitive QuantaSep user interface simplifies method development and system operation, helping users quickly configure, monitor, and optimize purification processes. Automated workflows, real-time process monitoring, and graphical process visualization streamline operation and reduce training requirements.
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Intuitive Method Development
Method creation is streamlined through the intuitive QuantaSep Method Editor. Users can easily define process steps, including buffer selection, gradient profiles, and fraction collection criteria based on UV absorbance, conductivity, pH, air detection, time, or other process parameters. Event controls allow users to automate functions such as baseline zeroing, process pauses, and sequence transitions, enabling efficient and reproducible method execution.
Built-In Safety & Data Integrity
The QuantaSep systems are equipped with integrated safety and data-management features designed to support reliable operation and regulatory compliance. An active air trap minimizes bubble-trap dilution, while leak and pressure alarms, safety interlocks, software method checks, and security controls help protect both the process and data integrity.
cGMP Documentation and Data Analysis
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Comprehensive batch documentation captures all manual and automated events, including deviations, in the batch log. Detailed reports containing methods, buffers, alarms, events, chromatogram data, and analysis results can be printed or archived for full traceability. Instant Data Analysis provides real-time comparison against baseline data, enabling early detection of process deviations and reducing the risk of product loss.
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