OPTIC-4
Multimode Inlet for Gas Chromatograph-Mass Spectrometer
High-Performance Multimode Inlet
A Next-Generation Inlet Accommodating a Variety of Sample Forms

Equipped with injection modes capable of accommodating a wide range of sample forms, the OPTIC-4 is the ultimate inlet in GC-MS sample injection systems. Attaching the OPTIC-4 to the AOC-6000 Plus draws out its very best performance.
The wide range of injection modes offered by the OPTIC-4 multimode inlet makes it possible to accommodate many different sample forms. So, in addition to split/splitless injections, many other analyses, such as the pyrolysis analysis of solid samples and the thermal desorption analysis of odor components, can be performed.

Various liners
Simplifying Pretreatment—DMI
(Difficult Matrix Introduction)
With DMI, a microvial containing the sample is inserted in the liner, and the liner is then heated at the injection port before analyzing the sample. By adjusting the temperature of the injection port, non-volatile impurity components are left remaining in the microvial, enabling GC/MS measurements to be performed with a minimal amount of pretreatment.
After Trapping/Concentration Using MonoTrap™,
Thermal Desorption Provides High-Sensitivity Analysis
By using the MonoTrap*, which has a silica monolith structure and a high trapping efficiency, to trap volatile components in the sample, then using the OPTIC-4 for thermal desorption, analyses requiring higher sensitivity can be performed. Moreover, the high-speed heating function provides for rapid desorption of the trapped components, which results in acquisition of sharper peaks.
The liner placed in the rack, after removing its caps at the CDC station, is installed in the OPTIC-4 injection port.

* For further information on the MonoTrap, refer to the website of GL Sciences, Inc.
Sharper Peaks, Enhanced Separation
Due to a sample introduction path of only 1 cm, and the adoption of a high-speed heating system capable of 60 °C /s, sharper peaks are realized.

TD mode
There is only 1 cm between the sample and the tip of the analysis column. For this reason, the system is ideal for analysis of compounds with high adsorptivity or degradability.

MonoTrap used to analyze methanethiol in parmesan cheese

OPTIC-4 injection port
Peaks are made sharper by attaching a cryo-trap (option) to the GC oven. Samples trapped by the cryo-trap are heated rapidly, up to 60 °C/s, so the development of bands is kept to a minimum.
Intuitive Operation Using Dedicated Evolution Workstation Software
The dedicated Evolution Workstation software for the OPTIC-4 displays analysis conditions in a time chart for intuitive grasping and modification, enabling easy formulation of conditions. Optimization is easy, since methods accommodating various injection modes have been included.

Large volume injection method
Wide Variety of Injection Modes
The various injection modes allow analysis of many different sample forms.
Liner | Sample Introduction Method | Application Examples |
DMI | Thermal extraction | Content of 1,4-dioxane in shampoo |
MonoTrap TD | Thermal desorption | Odor from Clothing |
MonoTrap TD | Thermal desorption | Odor from product |
DMI | Pyrolysis | Pyrolysis of resin |
DMI | Reactive Pyrolysis | Reactive Pyrolysis of Resin |
Solid adsorption agent (TD) | Thermal desorption | Atmospheric gas in automobile |
DMI | Thermal extraction | Reactive Pyrolysis of Resin |
MonoTrap TD | Thermal desorption | Aroma from Food Products |
News / Events
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Life Science Biomarker Industry Page has been updated
Biomarkers are derived from living organisms and found in tissues, blood, and other bodily fluids. Biomarkers are indicators of biological changes in an organism and are used to diagnose disease, in prognosis, and to evaluate the efficacy and safety of pharmaceuticals. Biomarkers can be nucleic acids, proteins, peptides, lipids, and sugars, and are identified using various “omics” techniques.
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Life Science Proteomics Industry Page has been updated
Proteomics is an academic discipline involving the comprehensive study of protein structure and function, typically by mass spectrometry and electrophoresis. Unlike the genome, the cells of an organism do not all contain the same complement of proteins, but different cells contain different proteins at different times. Proteomics uses this phenomenon to enable more efficient drug development and to determine the mechanisms of disease.
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Sports doping
Anti-doping policies, rules and regulations are governed by the World Anti-Doping Agency (WADA). Doping is not only harmful to athletes who take performance-boosting drugs, but also affects the integrity of a sport. Shimadzu instruments can help ensure clean sports and here are a few applications.
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Shimadzu has released Peakintelligence™ for GCMS
Peakintelligence for GCMS is equipped with new AI peak integration algorithms that significantly shorten the time needed for peak integration in the GC/MS/MS quantitative processing work sequence. AI algorithms trained with peak integration know-how provide peak integration on par with that of an experienced user, so configuring or adjusting parameters is not required. In addition, the software can correctly detect low-concentration samples.
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What is a Method Package?
Method Package contains ready-to-use analytical conditions and sample pretreatment procedures optimized for Shimadzu mass spectrometers and specific analytical applications.
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Shimadzu has released the Smart Metabolites Database™ Ver.2
The Smart Metabolites Database™ is a GC-MS(/MS) database that contains the information needed for analyzing metabolic components. In Ver.2, the number of registered components is increased to expand the reach of the analysis of food samples, focusing on plant secondary metabolites such as catechins and chlorogenic acids that are garnering interest as functional components to enable simultaneous analysis of over 600 components.