LC/MS/MS Rapid Toxicology Screening System Ver.3
For LabSolutions™ LCMS
Library info for 231 compounds common in toxicology
This system improves the efficiency of simultaneous LC/MS/MS analysis methods by allowing the user to start analysis without time-consuming steps such as consideration of separation conditions and MS parameter optimization.
Rapid simultaneous analysis methods with analysis times under 15 mins are included for 231 compounds including drugs of abuse, psychoneurotic drugs and sedatives. The system also provides optimised conditions for synchronised survey scans used in screening measurements (conditions adopted for the product ion spectrum as a threshold value for the intensity in MRM).
Total solution including semi-quantitation
For each compound in the method, calibration curve information based on internal standards is available, so it is possible to obtain simple quantitative values after analysis. Using a pretreatment method based on the QuEChERS method*, it is possible to comprehensively recover compounds from biological samples. Qualitative analysis using the spectral library can be carried out during the data processing stage. In other words, the system provides a total solution encompassing pretreatment, analysis and data processing.
Pretreatment using the Micro Volume QuEChERS Kit
Example of data analysis using LabSolutions Insight Library Screening:
Using LabSolutions Insight Library Screening, you can check all of the following:
- (1) Quantitative results
- (2) Library search results
- (3) MS chromatogram
- (4) MS/MS spectra
- (5) Structural formula
List of registered compounds:
231 compounds including illegal drugs, sedatives, psychotropic drugs and medical drugs associated with many real-life cases.
Ecgonine methyl ester
Remarks and Precautions
- LabSolutions LCMS Ver. 5.109 or later and LabSolutions Insight Ver. 3.8SP1 or later are required.
- Depending on the condition and specifics of the equipment used, differences in quantitative values may occur. For accurate quantitative values, please use a calibration curve method with appropriate standard samples. In addition, scores obtained from searching in the library show the similarity of spectra and form one basis for the identification of compounds, but for more accurate compound identification it is more effective to combine multifaceted information such as retention times and sample information.
LabSolutions is a trademark of Shimadzu Corporation or its affiliated companies in Japan and/or other countries.
For Research Use Only. Not for use in diagnostic procedures.
News / Events
Shimadzu has released High Resolution Accurate Mass Library for Forensic Toxicology
The High Resolution Accurate Mass (HRAM) Library includes two MS/MS spectral libraries. Each library is built using two different separation conditions and is suitable for targeted or non-targeted screening of drugs of abuse, psychotropic drugs, pharmaceuticals, pesticides, and other compounds of toxicological interest.
What is a Method Package?
Method Package contains ready-to-use analytical conditions and sample pretreatment procedures optimized for Shimadzu mass spectrometers and specific analytical applications.
Shimadzu has released the LC/MS/MS Methid Package for Glycosaminoglycans
The study of Glycosaminoglycans (GAGs) or mucopolysaccharides, and enzymes involved in GAG metabolism is an important aspect of clinical research related to lysosomal storage. Quantitation of GAGs in bones, joints, the brain, heart, lungs, and other organs is a useful tool in this field of study. GAGs can be quantitated by measuring the sulfated disaccharides produced by enzymatic degradation of GAGs. The research group led by Hironori Kobayashi of Shimane University Hospital, Clinical Laboratory Division, has been instrumental in the development of methods for the detection of sulfated disaccharides by LC/MS.
Shimadzu has released the LC/MS/MS Method Package for PFAS in Drinking Water.
Provides procedures and methods for analyzing organofluorine compounds in drinking water according to EPA methods 533 and 537.1
Shimadzu has released the CoreFocus Library.
CoreFocus Library is a digital library where you can find and learn different methods for analyzing your target compounds.
Shimadzu has released the Peakintelligence™
Peakintelligence is a world-first algorithm incorporating AI assistance to search for chromatography peaks. Having learnt peak processing skills from experienced users, the AI can process data with the same skill level. The algorithm can be implemented immediately without adjusting any parameters, and reduce wrong detection by 1/3 compared conventional algorithm with default setting.
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