By incorporating newly improved ion optics and collision cell technology, the LCMS-8040 provides higher multiple reaction monitoring (MRM) sensitivity.
LCMS-8040
Liquid Chromatograph Mass Spectrometer

The LCMS-8040 was designed to provide significantly higher sensitivity while maintaining the high speed offered by the LCMS-8030. Ultrafast MRM transition speeds, up to 555 MRMs per second (dwell times of 1 msec and pause times of 1 msec) are achieved. In addition, the LCMS-8040 features the polarity switching at 15 msec and high speed scanning rate of 15,000 u/sec. By incorporating newly improved ion optics UF-Lens™ and UFsweeper™ II collision cell technology, the LCMS-8040 provides higher multiple reaction monitoring (MRM) sensitivity. This higher sensitivity expands the potential range of LC/MS/MS applications.
Features
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Ultra-High Sensitivity
By incorporating newly improved ion optics and collision cell technology, the LCMS-8040 provides higher multiple reaction monitoring (MRM) sensitivity. -
Blood plasma samples were spiked with verapamil and warfarin, and then protein precipitation was carried out according to the pretreatment flow indicated below.
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Movies
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LCMS-8040 Triple quadrupole LC/MS/MS
The LCMS-8040 features the polarity switching at 15 msec and high speed scanning rate of 15,000 u/sec. By incorporating newly improved ion optics UF-Lens™ and UFsweeper™ II collision cell technology, the LCMS-8040 provides higher multiple reaction monitoring (MRM) sensitivity. This higher sensitivity expands the potential range of LC/MS/MS applications.
News / Events
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Life Science Biomarker Industry Page has been updated
Biomarkers are derived from living organisms and found in tissues, blood, and other bodily fluids. Biomarkers are indicators of biological changes in an organism and are used to diagnose disease, in prognosis, and to evaluate the efficacy and safety of pharmaceuticals. Biomarkers can be nucleic acids, proteins, peptides, lipids, and sugars, and are identified using various “omics” techniques.
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Life Science Proteomics Industry Page has been updated
Proteomics is an academic discipline involving the comprehensive study of protein structure and function, typically by mass spectrometry and electrophoresis. Unlike the genome, the cells of an organism do not all contain the same complement of proteins, but different cells contain different proteins at different times. Proteomics uses this phenomenon to enable more efficient drug development and to determine the mechanisms of disease.
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Cellulose nanofibers
Given that cellulose nanofibers(CNFs)offer attractive physical characteristics, such as light weight, strength, and hardness, they not only enable materials with advanced functionality, but are expected to be used as a reinforcing material that can reduce the weight of composite materials.
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Handbook of Analysis Procedures for EPA method 533, EPA method 537.1 are now available.
The validity of the analysis performed by each laboratory needs to be confirmed by Quality Control (QC). This article section shows the general analytical procedure for fulfilling QC requirements. Note that the procedure could be modified depending on the situation in the lab and analysts.
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Shimadzu has released the CLAM-2040, Fully Automated Sample Preparation Module for LCMS
The CLAM-2040 accompanies you on most of the analytical workflow and improves your overall throughput by drastically reducing the sample preparation time. Simply place the blood tubes in position and the CLAM-2040 performs the next steps automatically, from sample extraction, up to the LCMS analysis and data processing.
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Per- and Polyfluoroalkyl Substances (PFAS)
Per-and polyfluoroalkyl substances (PFAS) are a group of persistent and harmful chemicals that can be commonly found in the environment globally. These anthropogenic chemicals can come from various sources such as manufacturing, industrial applications, food contact materials and consumer products, and eventually end up and accumulate in the water, soil and living organisms.