Digital Ion Trap Mass Spectrometer
Despite its light and compact shape, the MALDImini-1 allows very high-sensitivity MSn measurements, making it suitable for a large number of applications.
Principle of MALDI/TOFMS
What is MALDI?
Matrix Assisted Laser Desorption/Ionization.
MALDI is the abbreviation for "Matrix Assisted Laser Desorption/Ionization."
The sample for MALDI is uniformly mixed in a large quantity of matrix.
The matrix absorbs the ultraviolet light (wavelength 337~355nm) and converts it to heat energy. A small part of the matrix (down to 100 nm from the top outer surface of the Analyte in the diagram) heats rapidly (in several nano seconds) and is vaporized, together with the sample.
Publications Refer [Koichi Tanaka Mass Spectrometry Research Laboratory]
Column Refer[Koichi Tanaka Mass Spectrometry Research Laboratory]
What is TOF MS?
TOF MS is the abbreviation for Time of Flight Mass Spectrometry.
Charged ions of various sizes are generated on the sample slide, as shown in the diagram. A potential difference V0 between the sample slide and ground attracts the ions in the direction shown in the diagram. The velocity of the attracted ions v is determined by the law of conservation of energy. As the potential difference V0 is constant with respect to all ions, ions with smaller m/z value (lighter ions) and more highly charged ions move faster through the drift space until they reach the detector. Consequently, the time of ion flight differs according to the mass-to-charge ratio (m/z) value of the ion. The method of mass spectrometry that exploits this phenomenon is called Time of Flight Mass Spectrometry.
Related Products
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Benchtop Linear MALDI-TOF Mass Spectrometer
The MALDI-8030 is the latest in a long line of MALDI-TOF products from Shimadzu.
Downloads
Download the latest brochure.
Applications
| Documents | Date Creation Date |
|---|---|
2024-09-27 | |
2020-06-24 | |
2018-06-12 |
News / Events
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INTERNATIONAL MASS SPECTROMETRY CONFERENCE 2024
Visit the Shimadzu booth at the International Mass Spectrometry Conference (IMSC) 2024.
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Maldi EasyCare Training Video has been uploaded.
The Shimadzu MALDI EasyCare solution offers a convenient way to perform routine maintenance on your system and increase your uptime. Manual cleaning of ion optics is safe, quick (period from venting to ion optics removal is approx. 10 mins), easy-to-do requiring no tools (except single-point use of flat blade screwdriver) and no technical expertise due to full guidance by software wizard. All cleaning materials provided.
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Shimadzu has released the MALDI-EasyCare, Upgrade for the MALDI-8000 Series MALDI-TOF mass spectrometers
Maintain optimal performance of your system using MALDI EasyCare to manually clean the ion optics and autotune the instrument.
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Shimadzu has released the FlexiFocus™
The FlexiFocus adaptor has been specifically designed to hold a FlexiFocus insert and position it optimally for analysis in the Shimadzu MALDI-8020 and MALDI-8030 benchtop MALDI-TOF instruments.
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Latest issue of Shimadzu Journal, featuring Forensics / Toxicology, has come out.
This issue focuses on "Forensics / Toxicology", an area where science and technology are particularly important and needed. It starts with two customer interviews.
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Life Science Biomarker Industry Page has been updated
Biomarkers are derived from living organisms and found in tissues, blood, and other bodily fluids. Biomarkers are indicators of biological changes in an organism and are used to diagnose disease, in prognosis, and to evaluate the efficacy and safety of pharmaceuticals. Biomarkers can be nucleic acids, proteins, peptides, lipids, and sugars, and are identified using various “omics” techniques.