PRESENTATIONS : ACHIEVEMENTS : Shimadzu Analytical Innovation Research Laboratory : SHIMADZU CORPORATION

2026

2026.07

Ionization Model of Oligonucleotides in LC/MS with Hydrophilic Mobile Phase Additives

The 11th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan

Takashi Miyazaki^1,2,3
Satoshi Yamaki³
Takao Yamaguchi¹
Satoshi Obika¹

¹Graduate School of Pharmaceutical Sciences, The University of Osaka
²Shimadzu Analytical Innovation Research Laboratories, The University of Osaka
³Shimadzu Corporation

2026.06

Anaerobic processing enhances γ-aminobutyric acid (GABA) production and α-glucosidase inhibitory activity in tempe

Metabolomics2026

Chiaki Tsushi^1,2,3
Eiichiro Fukusaki^1,3,4,5
Sastia Prama Putri^1,3,4

¹Department of Biotechnology, Graduate School of Engineering, Osaka University,
²Life Science Business Department, Shimadzu Corporation,
³Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University,
⁴Institute for Open and Transdisciplinary Research Initiatives, Osaka University,
⁵Faculty of Biotechnology and Life Sciences, Sojo University

2026.06

Enhanced Ionization of Oligonucleotides by Hydrophilic Additives in LC/MS

The 74th Annual Conference on Mass Spectrometry, Japan

Takashi Miyazaki^1,2,3
Satoshi Yamaki³
Takao Yamaguchi¹
Satoshi Obika¹

¹Graduate School of Pharmaceutical Sciences, The University of Osaka
²Shimadzu Analytical Innovation Research Laboratories, The University of Osaka
³Shimadzu Corporation

2026.03

Hexafluoro-2-propanol-free liquid chromatography/mass spectrometry for oligonucleotide therapeutics

The 146th Annual Meeting of the Pharmaceutical Society of Japan

Takashi Miyazaki^1,2,3
Natsuyo Asano³
Satoshi Yamaki³
Takao Yamaguchi¹
Satoshi Obika¹

¹Graduate School of Pharmaceutical Sciences, The University of Osaka
²Shimadzu Analytical Innovation Research Laboratories, The University of Osaka
³Shimadzu Corporation

2025

2025.09

Construction of a genome-scale metabolic models for CHL-YN cells: Determination of key parameters

The Society for Biotechnology, Japan / Annual Meeting 2025

Masahiro Yamazaki^1,2,3
Hirotaka Kuroda^1,2,3
Noriko Yamano-Adachi^1,4
Takeshi Omasa^1,4

¹Grad. Sch. Eng., UOsaka
²Shimadzu Corp.
³Shimadzu Analytical Innovation Research Lab.
⁴OTRI., Uosaka

2025.07

Development of a Novel Hexafluoro-2-propanol-Free LC/MS Analytical Method for Oligonucleotide

The 10th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan

Takashi Miyazaki^1,2,3
Natsuyo Asano³
Satoshi Yamaki³
Takao Yamaguchi¹
Satoshi Obika¹

¹Graduate School of Pharmaceutical Sciences, The University of Osaka
²Shimadzu Analytical Innovation Research Laboratories, The University of Osaka
³Shimadzu Corporation

2025.06

Multimass Analysis of Adeno-Associated Virus Vectors by Orbitrap-Based Charge Detection Mass Spectrometry

The 10th Asia Oceania Mass Spectrometry Conference

Ryoji Nakatsuka^1,2,3
Yuki Yamaguchi¹
Kiichi Hirohata¹
Saki Shimojo¹
Makoto Murakami¹
Mark Allen Rocafort⁴
Yasuo Tsunaka¹
Mitsuko Fukuhara^1,4
Tetsuo Torisu¹
Susumu Uchiyama¹

¹Osaka Univ.
²Shimadzu Corp.
³Osaka Univ. Shimadzu Analytical Innovation Research Laboratories
⁴U-Medico Inc.

2025.06

Development of Hexafluoro-2-propanol-Free LC/MS Method for Oligonucleotide Analysis

The 10th Asia-Oceania Mass Spectrometry Conference (AOMSC 2025)

Takashi Miyazaki^1,2,3
Natsuyo Asano³
Takao Yamaguchi¹
Satoshi Obika¹

¹Graduate School of Pharmaceutical Sciences, The University of Osaka
²Shimadzu Analytical Innovation Research Laboratories, The University of Osaka
³Shimadzu Corporation

2025.01

Analysis of genome encapsidated in Adeno-associated virus vector by orbitrap-based charge detection mass spectrometry

The 73rd American Society for Mass Spectrometry

Ryoji Nakatsuka^*1,2,3
Yuki Yamaguchi ¹
Aoba Matsushita ⁴
Yasuo Tsunaka ¹
Mitsuko Fukuhara ^1,4
Tetsuo Torisu ¹
Susumu Uchiyama ¹

¹Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Japan
²Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan
³Osaka University Shimadzu Analytical Innovation Research Laboratories, Osaka University, Suita, Japan
⁴U-Medico Inc, Suita, Japan

2024

2024.11

Analysis of Ionizable Lipids and Their Metabolites in Mouse Liver Using LC/MS: Supporting LNP Development

The 47th annual meeting of the Molecular Biology Society of Japan

Qiuyi Wang^1,2
Tsuyoshi Nakanishi ¹
Sachiko Sakamoto ³
Keiko Kajiwara ³
Kaoru Nakagawa¹
Arisa Ito ²
Ayako Matsunawa ³
Hiroyuki Tanaka ³
Masayuki Sugimoto ³
Hirofumi Ebe ³
Kenjiro Minomi ³
Natsuyo Asano¹
Naoki Morita¹
Tadayuki Yamaguchi¹
Junko Iida^1,2

¹Shimadzu Corporation
²Shimadzu Analytical Innovation Research Laboratories, Osaka University
³Nitto Denko Corporation

2024.11

Why is Wagyu special? : A comprehensive analysis of the elements of Wagyu beef relative to other beef for the design of cultured Wagyu beef

ISCCM10

Chika Nakadozono^1,2,3,4
Junko Iida^2,3
Ryo Kubota2,Shinsuke Inoue^2,4
Yoshihiro Kodama^4,5
Asuka Yamada^1,4
Akiko Takasuga^4,6
Takuya Sugiura^4,6
Fiona Louis⁷
Marie Piantino⁴
Quentin Muller⁴
Michiya Matsusaki^1,4

¹Department of Applied Chemistry, Graduate school of Engineering, Osaka University, Japan
²Shimadzu Corporation, Japan
³Shimadzu Analytical Innovation Research Laboratories, Osaka university, Japan
⁴Consortium for Future Innovation by Cultured Meat, Japan
⁵TOPPN Holdings Inc., Japan
⁶ITOHAM YONEKYU HOLDINGS INC., Japan
⁷Joint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry Graduate School Engineering,Osaka University, Japan

2024.11

Expansion of Social Capital and Its Factors in the REACH Project

The 27th Annual Academic Conference of The Japanese Association of Administrative Science

Daisuke Hiramaru^1,2,3
Hiroya Hirakimoto¹

¹Graduate School of Economics, Osaka University
²Shimadzu Analytical Innovation Research Laboratories, Osaka University
³Shimadzu Corporation

2024.10

The REACH Project, implemented by Shimadzu Corporation, which aims to develop human resources through joint research

The 39th Annual Academic Conference of Japan Society for Research Policy and Innovation Management

Daisuke Hiramaru¹
Hiroaki Nakanishi¹
Junko Iida¹

¹Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University

2024.10

Analysis of Metabolites in Tea Leaves Containing Catechins Using Triple Quadrupole LC-MS/MS

The 18th Metabolome Symposium

Yuki Ito^1,2
Arisa Ito²
Jun Watanabe^1,2
Junko Iida^1,2

¹Shimadzu Corporation
²Shimadzu Analytical Innovation Research Laboratries

2024.10

Improvement of Metabolite Stability by Storing Samples Using Silica Monolith

The 18th Metabolome Symposium

Kazuhiro KAWAMURA^1,2,3
Taito KUMANO¹
Eiichiro FUKUSAKI^1,3,4

¹Department of Biotechnology, Graduate School of Engineering, Osaka University
²Life Science Business Department, Shimadzu Corporation
³Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
⁴Institute for Open and Transdisciplinary Research Initiatives, Osaka University

2024.10

Extending a Bayesian Method for Inferring Constituent Information using MS/MS Data

SciX 2024

Taichi Tomono^*1,2,4
Satoshi Hara¹
Junko Iida^3,4
Takashi Washio¹

¹Department of Reasoning for Intelligence, The institute of Scientific and Industrial Research, Osaka University
²AI Solution Unit, Technology Research Laboratory, Shimadzu Corporation
³Life Science Business Department, Analytical & Measuring Instruments Division, Shimadzu Corporation
⁴Shimadzu Analytical Innovation Research Laboratories, Osaka University

2024.10

A Novel Sampling and Gas-Phase Derivatization Strategy Using Silica Monoliths for Gas Chromatography-Mass Spectrometry-based Metabolomics

The International Symposium on Chromatography 2024

Kazuhiro KAWAMURA^1,2,3
Eiichiro FUKUSAKI^1,3,4

¹Department of Biotechnology, Graduate School of Engineering, Osaka University, Japan
²Life Science Business Department, Shimadzu Corporation, Japan
³Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University, Japan
⁴Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Japan

2024.10

Ultra-Fast Scanning Quadrupole Mass Spectrometry Combined with GCxGC for Comprehensive Analysis of Complex Matrix Samples

The International Symposium on Chromatography 2024

Kazuhiro KAWAMURA^1,2
Toshinari ISHII¹
Kei USUI¹
Yu NAGAO¹

¹Shimadzu Corporation, Japan
²Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University, Japan

2024.10

Application of supercritical fluid chromatography to deamination analysis of oligonucleotides

The 20th Annual Oligonucleotide Therapeutics Society Meeting

〇Momoka Hayashida ^1,2,3
Risa Suzuki ³
Shinnosuke Horie ^2,3,4
Junichi Masuda ³
Takao Yamaguchi ¹
Satoshi Obika ¹

¹ Graduate School of Pharmaceutical Sciences, Osaka University
²Osaka University Shimadzu Analytical Innovation Research Laboratories
³Shimadzu Corporation
⁴Shimadzu Europa GmbH

2024.09

Analysis of Ionizable Lipids and Their Metabolites in Mouse Liver Using LC/MS: Supporting LNP Development

The 50th Anniversary Symposium of Biological Mass Spectrometry Conference

Qiuyi Wang ^{1, 2}
Tsuyoshi Nakanishi ¹
Sachiko Sakamoto ³
Keiko Kajiwara ³
Kaoru Nakagawa ¹
Arisa Ito ²
Ayako Matsunawa ³
Hiroyuki Tanaka ³
Masayuki Sugimoto ³
Hirofumi Ebe ³
Kenjiro Minomi ³
Natsuyo Asano ¹
Naoki Morita ¹
Tadayuki Yamaguchi ¹
Junko Iida ^{1, 2}

¹Shimadzu Corporation
²Shimadzu Analytical Innovation Research Laboratories, Osaka University
³Nitto Denko Corporation

2024.07

Analysis of SM-102 and its Metabolites in Mouse Liver using LC/MS

The 9th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan

Qiuyi Wang ^{1, 2}
Tsuyoshi Nakanishi ¹
Sachiko Sakamoto ³
Keiko Kajiwara ³
Kaoru Nakagawa ¹
Arisa Ito ²
Ayako Matsunawa ³
Hiroyuki Tanaka ³
Masayuki Sugimoto ³
Hirofumi Ebe ³
Kenjiro Minomi ³
Natsuyo Asano ¹
Naoki Morita ¹
Tadayuki Yamaguchi ¹
Junko Iida ^{1, 2}

¹Shimadzu Corporation
²Shimadzu Analytical Innovation Research Laboratories, Osaka University
³Nitto Denko Corporation

2024.07

Suitability of supercritical fluid chromatography for deamination analysis of oligonucleotides

The 9th Annual Meeting of Nucleic Acids Therapeutics Society of Japan

〇Momoka Hayashida ^1,2,3
Risa Suzuki ³
Shinnosuke Horie ^2,3,4
Junichi Masuda ³
Takao Yamaguchi ¹
Satoshi Obika ¹

¹Graduate School of Pharmaceutical Sciences, Osaka University
²Osaka University Shimadzu Omics Innovation Research Laboratories
³Shimadzu Corporation
⁴Shimadzu Europa GmbH

2024.07

Deepening and Evolution of Industry on Campus (3) -REACH Project Aiming for Human Resource Development through Collaborative Research with Shimadzu Corporation-

22th Annual Meeting of Japan Society for Intellectual Production

Daisuke Hiramaru¹
Hiroaki Nakanishi¹
Junko Iida¹

¹Osaka University Shimadzu Omics Innovation Research Laboratory, Osaka University

2024.06

Blending of chemically-defined liquid media for efficient screening of medium components in antibody production

The European Society for the Advancement of Cell Technology 2024

Hirotaka Kuroda^1,2,3
Kazuya Sorada¹
Noriko Yamano-Adachi¹
Junko Iida^2,3
Takeshi Omasa¹

¹Grad. Sch. Eng., Osaka Univ.
²Shimadzu Corp.
³Shimadzu Analytical Innovation Research Lab.

2024.06

A Novel Sampling and Gas-Phase Derivatization Strategy: Proof of Concept for Analysis of Ionic Polar Metabolites Using Gas Chromatography-Mass Spectrometry

Metabolomics2024

Kazuhiro KAWAMURA^1,2,3
Eiichiro FUKUSAKI^1,3,4

¹Department of Biotechnology, Graduate School of Engineering, Osaka University
²Life Science Business Department, Shimadzu Corporation
³Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
⁴Institute for Open and Transdisciplinary Research Initiatives, Osaka University

2024.06

Analysis of amino acids in European house crickets (Acheta domesticus) using LC-MS/MS

The 72nd Annual Conference on Mass Spectometry, Japan

M. Yagame ¹
M. Sagara ¹
Arisa Ito ²
Q. Wang ^2,3
S. Ota ⁴
Y. Matsui ⁵
J. Watanabe ³

¹null co., ltd.
²Shimadzu Analytical Innovation Research Laboratries
³Shimadzu Corporation
⁴SOUSYA Co., ltd.
⁵BugMo Co., ltd.

2024.06

Comparison of Insect Frass Tea and Commercial Tea with LC/MS/MS and GC/MS analysis

The 72nd Annual Conference on Mass Spectometry, Japan

Tsuyoshi Maruoka ¹
Yuki Ito ^2,3
Jun Watanabe ^2,3
Junko Iida ^2,3
Naoki Mori ¹

¹Graduate School of Agriculture, Kyoto University
²Shimadzu Corporation
³Shimadzu Analytical Innovation Research Laboratries

2024.06

Advanced Stochastic Variational Inference for Accurate Constituent Estimation in Nucleic Acid Mixture Models

ASMS2024

Taichi Tomono^*1,2,4
Satoshi Hara¹
Junko Iida^3,4
and Takashi Washio¹

¹Department of Reasoning for Intelligence, The institute of Scientific and Industrial Research, Osaka University
²AI Solution Unit, Technology Research Laboratory, Shimadzu Corporation
³Life Science Business Department, Analytical & Measuring Instruments Division, Shimadzu Corporation
⁴Shimadzu Analytical Innovation Research Laboratories, Osaka University

2024.06

Comparison of the Empty/Full ratio assessment by Direct Mass Technology, Analytical Ultracentrifugation and Mass Photometry for AAV vectors.

ASMS2024

Ryoji Nakatsuka^{1, 2, 3}
Yuki Yamaguchi¹
Tatsuya Aisu¹
Kiichi Hirohata¹
Saki Shimojo¹
Aoba Matsushita¹
Yasuo Tsunaka¹
Mitsuko Fukuhara^{1, 4}
Tetsuo Torisu¹
Susumu Uchiyama¹

¹Department of Biotechnology, Graduate School of Engineering, Osaka University
²Technology Research Laboratory, Shimadzu Corporation
³Osaka University Shimadzu Analytical Innovation Research Laboratories, Osaka University
⁴U-Medico Inc

2024.05

Separation of deaminated impurities contained in synthesized oligonucleotides using supercritical fluid chromatography

TIDES USA 2024

〇Momoka Hayashida ^1,2,3
Risa Suzuki ³
Shinnosuke Horie ^2,3,4
Junichi Masuda ³
Takao Yamaguchi ¹
Satoshi Obika ¹

¹Graduate School of Pharmaceutical Sciences, Osaka University
²Shimadzu Analytical Innovation Research Laboratories
³Shimadzu Corporation
⁴Shimadzu Europa GmbH

2024.02

Development of the Method for Oligonucleotide Analysis using Supercritical Fluid Chromatography

Japan Society for SFC

〇Momoka Hayashida ^1,2,3
Risa Suzuki ³
Shinnosuke Horie ^2,3,4
Junichi Masuda ³
Takao Yamaguchi ¹
Satoshi Obika ¹

¹Graduate School of Pharmaceutical Sciences, Osaka University
²Osaka University Shimadzu Omics Innovation Research Laboratories
³Shimadzu Corporation
⁴Shimadzu Europa GmbH

2023

2023.11

The Metabolic Analysis of CHL-YN Cell through the Analysis of Organic / Inorganic Components in Culture Supernatant

JAACT2023 Nagoya（The 36th Annual and International Meeting of the Japanese Association for Animal Cell Technology）

Hirotaka Kuroda ^1,2,3
Akari Noma ¹
Kazuya Sorada ¹
Noriko Yamano-Adachi ¹
Junko Iida ^2,3
Takeshi Omasa ¹

¹Grad. Sch. Eng., Osaka Univ.
²Shimadzu Corp.
³Shimadzu Analytical Innovation Research Lab.

2023.11

Profiling of the N-linked Glycans of IgG Produced by CHL-YN Cells

JAACT2023（The 36th Annual and International Meeting of the Japanese Association for Animal Cell Technology）

Hirotaka Kuroda ^1,2,3
Akari Noma ¹
Mayu Okajima ²
Kazuya Sorada ¹
Noriko Yamano-Adachi ¹
Junko Iida ^2,3
Takeshi Omasa ¹

¹Grad. Sch. Eng., Osaka Univ.
²Shimadzu Corp.
³Shimadzu Analytical Innovation Research Lab.

2023.10

Examination of Modifier Composition for Oligonucleotide Analysis using Supercritical Fluid Chromatography

The 34th Annual Meeting of The Society for Chromatographic Sciences

Momoka Hayashida ^1,2,3
Risa Suzuki ³
Shinnosuke Horie ^2,3,4
Junichi Masuda ³
Takao Yamaguchi ¹
Satoshi Obika ¹

¹Graduate School of Pharmaceutical Sciences, Osaka University
²Shimadzu Analytical Innovation Research Laboratories
³Shimadzu Corporation
⁴Shimadzu Europa GmbH

2023.10

Comprehensive Analysis of Primary Metabolites Derived from Insects and Exploration of Distinctive Nutritional Components

The 17th Metabolome Symposium

Mai Yagame ¹
Arisa Ito ²
Qiuyi Wang ^2,3
Shinya Ota ⁴
Yusuke Matsui ⁵
Jun Watanabe ^2,3

¹null co., ltd., Japan
²Shimadzu Analytical Innovation Research Laboratories, Osaka University, Japan
³Shimadzu Corporation, Japan
⁴SOUSYA Co., Ltd., Japan
⁵BugMo Co., Ltd., Japan

2023.10

Development of a Novel Gas Phase Derivatization-GC/MS Method for Ionic Polar Metabolites using Silica Monolith as a Carrier

The 17th Metabolome Symposium

Kazuhiro Kawamura ^1,2,3
Eichiro Fukusaki ^1,3,4

¹Graduate School of Engineering, Osaka University
²Shimadzu Corporation
³Osaka University-Shimadzu Omics Innovation Research Laboratories, Osaka University
⁴Institute for Open and Transdisciplinary Research Initiatives, OTRI, Osaka University

2023.10