Achievements
  • Presentations at Conferences
  • Publication
2021.05

Evaluation of change in metabolome caused by comprehensive diabetes treatment: A prospective observational study of diabetes inpatients with gas chromatography/mass spectrometry-based non-target metabolomic analysis

journal of diabetes investigation

  • Naohiro Taya 1
  • Naoto Katakami 1,2
  • Kazuo Omori 1
  • Shoya Arakawa 3
  • Shigero Hosoe 1
  • Hirotaka Watanabe 1
  • Mitsuyoshi Takahara 1,4
  • Kazuyuki Miyashita 1
  • Hitoshi Nishizawa 1
  • Taka-Aki Matsuoka 1
  • Masahiro Furuno 3
  • Takeshi Bamba 5
  • Junko Iida 6,7
  • Eiichiro Fukusaki 3
  • Iichiro Shimomura 1
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  • 1 Department of Metabolic Medicine, Osaka University Graduate School of Medicine
  • 2 Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine
  • 3 Laboratory of Bioresource Engineering, Department of Biotechnology, Graduate School of Engineering, Osaka University
  • 4 Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University
  • 5 Division of Metabolomics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University
  • 6 Shimadzu Corporation
  • 7 Osaka University Shimadzu Omics Innovation Research Laboratories, Graduate School of Engineering, Osaka University
2021.02

Fake metabolomics chromatogram generation for facilitating deep learning of peak-picking neural networks

Journal of Bioscience and Bioengineering

  • Shinji Kanazawa 1,2,3
  • Akira Noda 1
  • Arisa Ito 2
  • Kyoko Hashimoto 2
  • Akihiro Kunisawa 1
  • Tsuyoshi Nakanishi 1
  • Shigeki Kajihara 1
  • Norio Mukai 1
  • Junko Iida 1,2
  • Eiichiro Fukusaki 4
  • Fumio Matsuda 3
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  • 1 Shimadzu Corporation
  • 2 Osaka University Shimadzu Omics Innovation Research Laboratories, Osaka University
  • 3 Graduate School of Information Science and Technology, Osaka University
  • 4 Graduate School of Engineering, Osaka University
2019.08

Fragmentation of Dicarboxylic and Tricarboxylic Acids in the Krebs Cycle Using GC-EI-MS and GC-EI-MS/MS

Mass Spectrometry

  • Nobuyuki Okahashi 1
  • Shuichi Kawana 2
  • Junko Iida 2,3
  • Hiroshi Shimizu 1
  • Fumio Matsuda 1
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  • 1 Graduate School of Information Science and Technology, Osaka University
  • 2 Shimadzu Corporation
  • 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
2018.09

Sugar phosphate analysis with baseline separation and soft ionization by gas chromatography-negative chemical ionization-mass spectrometry improves flux estimation of bidirectional reactions in cancer cells

Metabolic Engineering (2018)

  • Nobuyuki Okahashi 1
  • Kousuke Maeda 1
  • Shuichi Kawana 2
  • Junko Iida 2,3
  • Hiroshi Shimizu 1
  • Fumio Matsuda 1
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  • 1 Graduate School of Information Science and Technology, Osaka University
  • 2 Shimadzu Corporation
  • 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
2018.08

FK960 binding proteins, quinone oxidoreductase2 and pyridoxal kinase were identified by LC-MS/MS for drug discovery of Alzheimer's treatment

Trends in Research (2018), DOI:10.15761/TR.1000113

  • Zenzaburo Tozuka 1,2,3
  • Akihiro Kunisawa 2
  • Fumiyuki Shirai 3,4
  • Yoshinori Ishii 3,4
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  • 1 Graduate School of Pharmaceutical Science, Osaka University
  • 2 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
  • 3 Fujisawa Pharmaceutical Co., Ltd.
  • 4 Astellas Pharma Inc.
2018.07

Multi omics by LC-MS/MS to search small molecule ligands of nuclear receptors to control transcription of pharmaceutical active proteins for drug discovery

Trends in Research (2018), DOI: 10.15761/TR.1000111

  • Zenzaburo Tozuka 1
  • Akihiro Kunisawa 1
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  • 1 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
2018.01

Free D-amino acids produced by commensal bacteria in the colonic lumen

Scientific Reports (2018), DOI:10.1038/s41598-018-36244-z

  • Mitsuharu Matsumoto 1
  • Akihiro Kunisawa 2,3
  • Takanari Hattori 2,3
  • Shuichi Kawana 2
  • Yusuke Kitada 1
  • Hazuki Tamada 1
  • Shinichi Kawano 2,3
  • Yoshihiro Hayakawa 2
  • Junko Iida 2,3
  • Eiichiro Fukusaki 3,4
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  • 1 Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd
  • 2 Shimadzu Corporation
  • 3 Osaka University Shimadzu Analytical Innovation Research Laboratory, Osaka University
  • 4 Graduate School of Information Science and Technology, Osaka University
2016.6

GC-MS/MS survey of collision-induced dissociation of tert-butyldimethylsilyl-derivatized amino acids and its application to 13C-metabolic flux analysis of Escherichia coli central metabolism

Analytical and Bioanalytical Chemistry, June, 2016, in press.

  • Nobuyuki Okahashi 1
  • Shuichi Kawana 2
  • Junko Iida 2,3
  • Hiroshi Shimizu 1
  • Fumio Matsuda 1
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  • 1 Graduate School of Information Science and Technology, Osaka University
  • 2 Shimadzu Co.
  • 3 Graduate School of Engineering, Osaka University
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