Multi-Residue Veterinary Drug Analysis of >200 Compounds using MRM Spectrum Mode by LC-MS/MS (C161)

Introduction

Veterinary drugs are used for therapeutic, metaphylactic, prophylactic and growth promotion purposes. To provide an assurance that food from animals is safe with regards to residues of veterinary medicines, regulatory authorities have established Maximum Residue Limits (MRL's) for certain drugs in target tissues and animal species. Some pharmacologically active compounds identified by regulatory authorities have been prohibited and their hazardousness at all levels are being considered (EU regulation EC 37/2010; Commission Decision 2003/181/EC; 21CFR Part 556 Tolerances for Residues of New Animal Drugs in Food). In this article, we describe how a triple quadrupole mass spectrometer, which is both highly sensitive and selective, contributes to reducing false positive and false negative reporting when using a measurement mode called MRM Spectrum mode. MRM Spectrum mode acquires a high number of fragment ion transitions for each target compound and generates fragmentation spectra that can be used in routine library searching and compound verification using reference library match scores.

August 31, 2017 GMT