Primary Structural Analysis of Proteins / Peptides- Application of Protein Sequencer -

Introduction

Understanding of pathological states and life phenomena has accelerated dramatically with recent widespread advances in the field of proteomics, which encompasses the exhaustive comparison and identification of expressed proteins in normal and disease-state tissues and cells. The scope of this investigation includes pathology, differences in type, genetic variation and cell abnormalities across a range of scientific disciplines. For example, investigation of the causes of disease and treatment methods, and the search for specific biomarkers associated with those diseases in the field of proteomics has grown rapidly. The word "proteomics" was coined in the early 1990s to indicate the entire set of proteins expressed in a specific cell type or organism associated with that genome. In general, there is very little in the way of change in the genome in a given type of organism, but the change in the proteome between organs and cells can be vast. In order for an organism to make its genetic information actually function, the process of gene expression is required. Proteins are extremely important tool molecules which elicit the expression of a wide range of gene functions. Proteome analysis is an indispensible tool for elucidating these mechanisms of interaction between the genome and proteome, and hence is referred to as the field of proteomics. However, viewed historically, proteome analysis has proved to be much more difficult compared to genome analysis.

November 28, 2016 GMT