Analysis of Cortisone Acetate Tablets by Nexera UC SFC System

Introduction

The United States Pharmacopeia (USP) monographs are widely referenced to ensure the quality of drug substances. The USP monographs offer reliable and robust methods, but some methods, especially those using normal phase HPLC, require harmful solvents. Many laboratories have desired to reduce the use of such solvents for health, safety, and cost. This application note shows an example of the analysis of cortisone acetate tablets according to the USP monograph. The original normal phase method was transferred to an SFC method with a conventional column, Shim-pack CLC-SIL, then a high- speed column, Shim-pack XR-SIL by using the Nexera UC SFC system.

February 13, 2015 GMT