High Speed Analysis of Pesticides Listed in Appendix Method 20-2 for the Complementary Items for Water Quality Management in Japan Using a Triple Quadrupole LC/MS/MS-

Introduction

In March 2018, Notification Nos.0328-1 to 4 were issued by the Director of the Water Supply Division, Pharmaceutical Safety and Environmental Health Bureau, MHLW and the number of pesticides listed in an inspection method for the Complementary Items for water quality management in Japan's water quality standards was greatly increased. The method is Appendix Method 20-2 which describes simultaneous analysis using a liquid chromatograph mass spectrometer system and the number of pesticides was increased to 181. A total of 113 pesticides were added. Of these, 7 are newly added pesticides and the remaining 106 are those that can be analyzed according to the analytical conditions of Appendix Method 20-2 but were already listed in other appendix methods. The other methods are Appendix Method5 and 5-2 for simultaneous analysis using a solid-phase extraction gas chromatograph mass spectrometer system, Appendix Method 18 for simultaneous analysis using a solid-phase extraction liquid chromatograph mass spectrometer system, Appendix Method 19 for analysis using a solid- phase extraction liquid chromatograph mass spectrometer system, and Appendix Method20 for simultaneous analysis using a liquid chromatograph mass spectrometer. This article introduces an example analysis in which the 181 pesticides are analyzed within a short time of 25 min. Also, based on the validation guidelines of the drinking water inspection method, the results of using the LCMS-8050 for evaluating 152 of the pesticides, excluding the 29 pesticides for which the method is regarded to be referential, are introduced as well.

June 28, 2018 GMT