Online dissolution of Metformin ER tablets using Electrolab Veritas-08 with Shimadzu Nexera FV

Introduction

Extended release (ER) or sustained release dosage forms are designed to release a drug at predetermined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects. This can be achieved through variety of formulations. Due to modified dosage forms, dissolution study to assess quality and absorption patterns must be checked over longer durations. This means the dissolution tests are in these cases generally run for more than 16 hours. Needless to say, this presents both technical and administrative challenges. Maintaining complete traceability and avoiding errors are big tasks in hand for lab managers running ER dissolution assays. Under these circumstances, it’s highly desired to have an automated workflow starting from setting up of batch and aliquoting till reporting. Such a set-up will also enable operations without the need of a chemist with complete reliability. Most critical aspect and need of hour, irrespective of formulation type is ensuring compliance. An automated setup with complete compliance is need of an hour so as to ensure higher productivity and reduced errors with full traceability.

January 7, 2020 GMT