High Speed Analysis of Topiramate in accordance with chapter 621 in USP 39

Introduction

High throughput analysis has been advanced dramatically in recent years with the increasing necessity to improve productivity and operational efficiency. Especially HPLC has also been in the spotlight thanks to significant advances in ultra- high-speed analysis technology, in particular ultra- high performance LC and micro-particle column packing material. The recently revised General Chapter 621 of the United States Pharmacopoeia (USP 621) now permits a degree of adjustment of HPLC and GC parameters, specifically aimed to satisfy the requirements of system suitability. Taken account of USP 621, this Application News introduces an example of isocratic analysis of Topiramate monograph in accordance with USP and still fulfilling the allowable adjustment criteria. Topiramate is an antiepilepsy drug and anticonvulsant. An example of analysis that can be completed in a significantly shorter time than that described in the USP General Chapter 621 is presented here.

April 12, 2019 GMT