A Sample Prep-Free Analysis of Drug Molecules with “Smart IS+” and “SMCI+” - Compound Identification -

User Benefits

- “Smart IS+” and “SMCI+” setups direct qualitative GC/MS analysis of polar compounds such as drug molecules - Choose between electron ionization and positive chemical ionization modes with “Smart IS+” setup or perform both ionization mode consecutively in a single GC/MS analysis - Perform positive chemical ionization safely with “SMCI+” setup since it requires only common laboratory solvents as reagent gas

Introduction

The discovery and development of new drugs go through a series of lengthy processes that commonly begins in the synthetic laboratory. After the successful identification of a drug pharmacophore, the preparation of analogues demands a constant supply of starting materials. A rapid qualitative analysis method to confirm the successful synthesis of starting materials and thereafter the drug candidates would be important to increase the speed of drug discovery. The usage of a direct probe as a sample inlet in GC/MS provides a rapid qualitative technique that eliminates the need for tedious sample preparation. It enables direct analysis of nonvolatile, polar, and large molecules which typically requires multistep derivatization procedures for GC/MS analysis. This article demonstrates the application of a direct probe in conjunction with a Smart EI/CI ion source (Smart IS) or solvent mediated chemical ionization (SMCI) unit for the analysis of drugs. The mass spectra of drug molecules generated by Smart IS and SMCI units will be evaluated.

May 27, 2021 GMT