Determination of Ticagrelor and its related impurities content from oral tablets as per proposed IP monograph UHPLC method

User Benefits

- Shimadzu Nexera XS can be effectively used for assay and related substances test of Ticagrelor tablets as per the proposed IP monograph UHPLC method - The Nexera XS easily meets with all the acceptance criteria as per the proposed IP monograph for Ticagrelor tablets

Introduction

Ticagrelor is a pharmaceutical drug used for the prevention of stroke, heart attack and other events in people with acute coronary syndrome, meaning problems with blood supply in the coronary arteries. It acts as a platelet aggregation inhibitor by antagonising the P2Y₁₂ receptor. The proposed Indian Pharmacopeia (IP) monograph defines an UHPLC (Ultra High-Performance Liquid Chromatography) method for high throughput fast analysis demanding a competent UHPLC system. Here, we demonstrate the analysis of Ticagrelor tablets as per the proposed monograph in Indian Pharmacopeia using Shimadzu Nexera XS fast LC system in compliance with system suitability requirements of the proposed monograph.

November 29, 2021 GMT