A Direct Method for the Determination of 13 Nitrosamines in Water by LCMS-8045 System

User Benefits

- Enables estimation of nitrosamines in water without any sample pretreatment - This method can also be employed for the waste-water containing high organic loads

Introduction

Overview : Nitrosamines (especially NDMA) have been monitored by FDA since 2018, because Nitrosamines may increase the risk of cancer. There are several recalls regarding NDMA detection in pharmaceutical products. Also, the presence of nitrosamines, primarily NDMA, is common in water and foods, including cured and grilled meats, dairy products, and vegetables. Occurrence of NDMA in water (including drinking, recycled and non-potable waters) is primarily driven by chloramination and ozonation of water that contains NDMA precursors. Industrial wastewater effluents from the manufacturing of cosmetics, pharmaceuticals, personal care products, rubber and tires, food and beverages, among others, contribute to the presence of NDMA precursors in municipal wastewater and other non- potable waters. Reported NDMA concentrations in these samples range from 5 – 20 ng/L all the way up to 1000 ng/L .The World Health Organization (WHO) has set a world guideline for NDMA at 100 ng/L in drinking water and similar guidelines have been established in different countries. However, industrial or municipal effluent guidelines for nitrosamines have not been established yet. US EPA Method 521 uses SPE followed by GC-MS/MS and is used for low level nitrosamine analysis in drinking water. However, SPE methods present several drawbacks for the extraction of nitrosamines from water samples containing suspended solids as particulates may clog the cartridge and prevent elution of the sample. In addition, high organic loads consume active sites of the SPE cartridge lowering the adsorption and recovery of analytes by SPE. Also, the concentration of the SPE eluent may cause the loss of NDMA due to its high volatility. A method is therefore needed for water samples with high TOC (Total Organic Carbon) and TSS (Total Suspended Solids) content. This application note describes ASTM D8456 a method for the analyses of thirteen nitrosamines using LC-MS/MS directly from water without any SPE pretreatment.

May 9, 2022 GMT