Chemical Reaction Tracking and Reaction Product Confirmation in Organic Synthesis Processes Using a MALDI-TOF Mass Spectrometer

User Benefits

- Rapid and easy analysis of reaction products with low risk in sample preparation and operation. - The presence of Br and Cl can be easily identified with class-leading MS resolution.

Introduction

In organic synthesis, it is extremely important to identify the reaction products and understand the progress of the reaction. Specifically, it is necessary to know what kinds of compounds exist in the reaction solution and in what proportions. The most simple and general method used for chemical reaction tracking is thin-layer chromatography (TLC). This technique utilizes the adsorptivity of analytes to silica gel as the stationary phase, which is different for each compound contained in the sample. However, because this method separates compounds based on polarity, it is often impossible to separate compounds with similar chemical structures. As a solution for that problem, this report describes the usefulness of semi-quantitative reaction tracking and product confirmation using a MALDI-TOF MS, which enables rapid measurement of chemical compounds.

May 16, 2022 GMT