Using the DPiMS-8060 Mass Spectrometer to Analyze Drugs in Plasma (2) -A Quantitative Analysis of Abiraterone-

User Benefits

- The concentration dependence of drugs in plasma is easily analyzed with this method. - The analytical results obtained are unaffected by column condition or degradation.

Introduction

Measuring the concentration of drugs in blood or plasma is a type of analysis frequently performed in the context of research and clinical sampling. Accordingly, techniques are needed for obtaining results quickly and easily. Currently, LC/MS systems are typically used to measure drug concentrations in samples. However, because of the columns used in LC/MS systems, matrix components originating from metabolic products, such as proteins in blood and plasma, must be carefully removed. If the samples are not pretreated in this way, they can cause degradation or changes to the condition of columns, which can affect the analytical results. Furthermore, inadequate pretreatment of samples can lead to instrument contamination, increasing the frequency of maintenance required. This article introduces an analysis method using the LCMS-8045 system equipped with the DPiMS-8060 probe electrospray ionization (PESI) unit. The concentration of abiraterone in commercial plasma is then measured with only simple deproteinization pretreatment.

June 28, 2022 GMT