Analysis of Metal Elements in Culture Medium Using ICPMS-2030

User Benefits

- Simultaneous analysis is possible for metal elements in culture medium. - Culture medium can be analyzed with only dilution using the ICPMS-2030. - ICPMS-2030 can perform accurate analysis of metal elements even in high-matrix medium.

Introduction

It has been reported that metal elements in culture medium are important in cell culture because they are taken up by cells and contribute to enzyme reactions and redox reactions. On the other hand, there is a risk of contamination of metal elements from raw materials and equipment in the culture medium manufacturing process, so the concentration of metal elements may differ among lots. Therefore, it is important to know the concentration profile of metal elements in the medium to realize reproducible cell culture. We measured multiple elements, mainly essential trace elements, using the ICPMS-2030, which can perform sensitive analysis of multiple elements simultaneously. In ICP-MS measurements, inorganic salts and organic compounds (matrices) contained in the medium may cause interference and interface clog, affecting analytical values. In this Application News, we evaluated the spike recovery rates and long-term stability in culture medium using the ICPMS-2030.

November 27, 2025 GMT