Qualitative Analysis of Drugs in Blood Using LCMS-9030 and MS/MS Spectral Libraries

User Benefits

- Qualitative screening of drugs using LCMS-9030 can be performed in 15 minutes. - LabSolutions Insight Discovery and High Resolution Accurate Mass Library for Forensic Toxicology Ver. 2 simplify the analysis of measurement data .

Introduction

Many forensic toxicological analyses are related to overdoses of prescription or over-the-counter drugs, and the majority of drugs consumed are psychiatric drugs such as sleeping drugs, antidepressants, and anti-anxiety drugs. Hikiji et al.1) reported 30 drugs that are at high risk of causing death due to overdose. In addition, Asano et al.2) reported the top 20 psychotropic drugs left in the places where bodies were discovered, and according to that, sleeping drugs, anti-anxiety drugs, antidepressants, and antipsychotic drugs were particularly common. Many of the drugs listed in both reports are the same and are considered important targets for forensic toxicological analysis. For this reason, forensic toxicological analysis requires a workflow that can reliably identify the important related components without any omissions. This application introduces an example of drug qualitative screening using the LCMS -9030 quadrupole time-of-flight (QTOF) mass spectrometer, LabSolutions Insight Discovery, and “High Resolution Accurate Mass Library for Forensic Toxicology Ver. 2”.

March 18, 2025 GMT